老年2型糖尿病患者子女血浆纤溶酶原激活物抑制物1活性与胰岛素抵抗的关系

Relationship between the activity of plasma plasminogen activator inhibitor type-1 and the insulin resistance in the children of the elderly with type 2 diabetes

目的:检测老年2型糖尿病患者子女血浆纤溶酶原激活物抑制物-1(plasmaplasminogenactivatorinhibitortype-1,PAI-1)活性,分析它们与血脂、血糖、体质量指数、腰臀比、胰岛素抵抗之间关系。方法:选择2002-01/12河北省人民医院健康查体者54例为对照组,男26例,女28例。选择同期在本院门诊就诊及住院2型糖尿病患者的子女92例为子女组,男44例,女48例。测定两组对象血脂、血糖,采用发色底物法测PAI-1活性,用稳态模型胰岛素抵抗指数(HOMA-IR)评估胰岛素抵抗。结果:子女组血浆PAI-1活性犤(0.73±0.30)kAU/L犦显著高于对照组犤(0.51±0.19)kAU/L犦(P<0.05)。子女组HOMA-IR明显高于对照组(P<0.01)。PAI-1活性与Ln空腹胰岛素,三酰甘油呈正相关(r=0.38,0.46,P<0.01);PAI-1活性与InHOMA-IR呈正相关(r=0.14,P<0.05)。结论:老年2型糖尿病患者子女血浆PAI-1活性升高,且PAI-1活性与胰岛素抵抗密切相关;PAI-1在2型糖尿病的发生发展中起着重要作用。

AIM:To measure the activity of plasma plasminogen activator inhibitor type-1(PAI-1) in the children of the elderly with type 2 diabetes mellitus(DM) and analyze the relation with blood lipid,blood sugar,body mass index(BMI),waist-to-hip ratio(WHR),insulin resistance(IR). METHODS:Fifty-four people for health examination in Hebei Provincial People's Hospital from January to December 2002 were selected as controls,including 26 males and 28 females.Meanwhile,92 children of the type 2 DM inpatients were selected as children group,including 44 males and 48 females.Blood lipid and blood sugar were measured,fasting plasma PAI-1 activity was measured by the synthetic chromogenic method using a colorimetric assay,and homeostasis model assessment insulin resistance(HOMA-IR) was used for analysis of IR. RESULTS:The activity of plasma PAI-1 was significantly higher in the children group[(0.73±0.30)kAU/L] than the control group[(0.51 ±0.19) kAU/L](P< 0.05).There was positively linear correlation between plasma PAI-1 activity and fasting insulin levels(r=0.38,P=0.001), triglycerides TG(r=0.46,P< 0.001), HOMA-IR (r=0.14,P=0.03). CONCLUSION:Serum PAI-1 activity increases in the children of the elderly with type 2 DM,and it is closely correlated with IR.PAI-1 plays an important role in the occurrence and development of type 2 DM.