复方中药四泰片对胰岛素抵抗综合征大鼠血压、血脂、血糖、胰岛素的影响(英文)

Therapeutic effects of sitai tablet on blood pressure,blood lipid,blood sugar and insulin of rats with insulin resistance syndrome

目的:探讨复方中药四泰片对胰岛素抵抗综合征(insulinresistancesyn-drome,IRS)大鼠、血压、血脂、血糖、胰岛素的影响。方法:选用清洁级雄性SD大鼠40只,按随机区组设计分为正常对照组、模型组、四泰片组、卡托普利组4组。采用高糖高脂饲料喂养大鼠8周,造成IRS大鼠模型,观察四泰片对IRS大鼠血压、血糖、血脂、胰岛素水平及胰岛素敏感性指数(insulinsensitivityindex,ISI)的影响。结果:治疗后四泰片组、卡托普利组大鼠收缩压犤(128±4),(110±2)mmHg,(1mmHg=0.133kPa)犦与治疗前犤(158±8),(157±7)mmHg犦和模型组犤(165±6)mmHg犦比较,差异具有显著性意义(t=11.86～28.99,P<0.01)。四泰片组大鼠总胆固醇、三酰甘油均较模型组下降(t=44.27,9.14,P<0.01),高密度脂蛋白胆固醇(highdensitylipoproteincholesterol,HDL-C)升高(t=703,P<0.01)。模型组大鼠空腹胰岛素(fastinginsulin,FINS)均升高,ISI下降,与正常对照组比较,差异均有显著性意义(t=7.14,9.35,P<0.01),胰岛素抵抗明显,造模成功;四泰片组、卡托普利组大鼠空腹血糖、FINS均下降,与模型组比较,差异均有显著性意义(t=11.95,6.71,P<0.01),卡托普利组空腹血糖与四泰片组比较,差异有显著性意义(t=8.33,P<0.01);四泰片组、卡托普利组ISI均升高,与模型组比?

AIM:To explore the effects of sitai tablet on blood pressure,blood lipid,blood sugar and insulin of rats with insulin resistance syndrome(IRS). METHODS:A total of 40 male clean SD rats were divided into normal control group,model group,sitai group and captopril group by randomized block design.The rats were fed with high-fat high sugar diet for 8 weeks to induce IRS.Then,sitai tablets were given to rats with IRS to observe the influence of sitai tablet on blood pressure,blood sugar,blood lipid,insulin levels and insulin sensitivity index(ISI) of them. RESULTS:The systolic pressure reduced from(158±8),(157±7)mm Hg before treatment to(128±4),(110±2)mm Hg after treatment in sitai group and captoril group respectively.There was also significant difference on systolic pressure of between sitai group,captopril group and model group[(165±6)mm Hg](t=11.86-28.99,P< 0.01).In sitai group,the total cholesterol(TC),triacylycerol(TG)decreased clearly than those in model group(t=44.27,9.14,P< 0.01),but high density lipoprotein cholesterol(HDL-C) increased(t=703,P< 0.01).There were increased fasting insulin(FINS) and decreased ISI in model group.There was significant difference on these indes between model group and normal control group(t =7.14,9.35,P< 0.01).The insulin resistance was evident so that the model was successfully established.The fasting blood sugar and FINS all reduced when comparing it between sitai group,captopsil group with model group,there was significant difference(t=11.95,6.71,P< 0.01).When comparing the fasting blood sugar in captoril group and sitai group,there was also difference(t=8.33,P< 0.01).The ISI all increased in sitai group and captoril group,there was difference between them and model group(t=9.82,9.35,P< 0.01). CONCLUSION:Sitai tablet can remarkably reduce the blood pressure,blood sugar and blood fat, and increase the sensibility of insulin so that it can improve the general effects of IRS.