抗生殖免疫抗体与不明原因反复自然流产的关系

Relationship between anti-reproductive antibodies and recurrent spontaneous abortion of unknown etiology

目的 :为探讨抗生殖免疫抗体与不明原因反复自然流产的关系。方法 :采用ELISA法检测 5 2例不明原因反复自然流产(流产组 )血清抗精子抗体 (AsAb)、抗子宫内膜抗体 (EmAb)、抗卵巢抗体 (AovAb)、抗心磷脂抗体 (AcAb)和抗绒毛膜促性腺激素抗体 (AhcGAb)的含量。结果 :流产组AsAb阳性 2 6 .92 % ,EmAb阳性 4 2 .30 % ,AovAb阳性 30 .76 % ,AcA阳性 4 6 .15 %和Ahc GAb阳性 4 8.0 7% ;流产组的各项抗生殖免疫抗体检出率均明显高于对照组。结论 :以上 5种抗生殖免疫抗体可干扰卵的发育成熟、排卵、受精、胚泡着床和胚胎发育等过程。抗生殖免疫抗体与不明原因反复自然流产关系十分密切。

Objective: To study the relationship b etween the anti-reproductive antibodies and recurrent spontaneous abortion of unknown etiology. Methods: Fifty-two patients with recurrent spontaneous abortion of unknown etiology were taken as abortion group;fifty healthy women were taken as control.The serum were detected for antisperm antibody (AsAb),antiendometrium antibody (EmAb),antiovary antibody (AovAb),anticardiolipin antibody (AcA) and anti-human chorionic gonadotropin antibody(AhcGAb)by ELISA methods. Results: In abortion group the positive rate were AsAb 26.9%, EmAb 42.30%,AovAb 30.76%,AcA 46.15%,AhcGAb 48.07%.There was significant difference in detected rate of all anti-reproductive antibodies between 2 groups. Conclusion: It is suggested that anti-reproductive antibodies may influence ovum matureness, ovulation, fertilization, fertilized ovum embedding, fetal development The close relation is noted between anti-reproductive antibodies and female infertility in this study.