移植肾内TGF-β_1表达与慢性移植物肾病的关系

Relationship on TGF-β_1 in allograft and chronic allograft nephropathy

为探讨转移生长因子 (TGF β1)与慢性移植物肾病 (CAN)的关系 ,该研究对 138例肾功能正常的肾移植受者术后检测尿TGF β1浓度 ,并挑选出浓度最高和最低各 2 0例构成组Ⅰ、组Ⅱ ,比较两组患者肾穿剌组织中TGF β1(TGF β1mRNA和TGF β1蛋白 )的表达量、3年后CAN的发生率 ,并检测CAN者肾组织中TGF β1的表达量。结果显示组ⅠTGF β1的表达量和 3年后CAN的发生率均明显大于组Ⅱ ,CAN者肾组织中TGF β1的表达量明显大于肾功正常时。TGF β1与慢性移植物肾病的发生有着密切的关联 ,肾移植后检测尿TGF

To identify the relation between TGF-β 1in allograft and chronic allograft nephropathy (CAN). Urine TGF-β 1 concentration was tested in 138 normal recipients. Twenty cases with higher urine TGF-β 1 concentrations were collected as groupⅠ,and other 20 cases with lower urine TGF-β 1 as group Ⅱ. In both groups biopsies were carried out, and TGF-β 1 and TGF-β 1mRNA in the tissues were tested. Three years later, the renal function was compared between the two groups. Biopsies were carried out in renal recipients who suffered from CAN l.3 years after study, there was more loss of renal function and more CAN cases in group I than in group Ⅱ .Express of TGF-β 1 and TGF-β 1mRNA in the allografts is more in group I.The differences in the two groups were significant. The findings suggest that there was a relationship between TGF-β 1 in kidneys and CAN. The level of urine TGF-β 1 after renal transplantation can predict renal function.