摘要
目的 探讨散发性Creutzfeldt Jakob病(sCJD)的临床、病理及影像学特点。方法 回顾性分析 12例sCJD患者的临床表现、脑电图(EEG)、影像学特点及病理资料。结果 (1)本组男7例,女5例,平均发 病年龄49岁;3例以视觉缺失急性起病,9例以智能下降,精神、行为异常或共济失调亚急性起病;12例均有 痴呆、肌阵挛和锥体外系体征。(2)9例脑电图(EEG)表现典型的、1例表现不典型的三相波,(3)12例头颅 MRI检查,5例出现双侧基底节区T2加权像WI对称性高信号;8例同时行弥散加权(DWI)扫描,均表现为额 叶或/和枕叶DWI高信号,并有5例伴双侧基底节区对称性DWI高信号。(4)1例尸检及6例脑活检均具备 CJD病理特点。结论 sCJD在具备典型临床表现基础上,动态EEG及头颅MRIDWI扫描可为CJD的早期临 床诊断提供依据。
Objective To investigate the clinical, pathological and imaging features of sporadic Creutzfeldt-Jakob disease (CJD). Methods The clinical, pathological, electroencephalogram (EEG) and imaging data of 12 cases of CJD were analyzed retrospectively.Results (1) 7 cases of the enrolled patients were male and 5 were female. The average onset age of them was 49 years old. 3 cases were acute onset by visual loss and 9 cases were subacute onset by hypophrenia, mental and behavior disorder or cerebellar ataxia. All the cases showed dementia, myoclonus and extrapyramidal sign. (2) 9 cases showed typical triphasic wave on EEG and 1 case presented atypical triphasic wave. (3) 5 cases showed abnormal hyperintense lesions in basal ganglia on T 2-weighted images (T 2WI). 8 cases in occipital and/or frontal cortex showed the abnormal hyperintense lesions on diffusion-weighted images (DWI), and 5 of them accompanied symmetric diffuse hyperintense lesions in basal ganglia. (4) 1 case with postmortem and 6 cases with biopsy of brain showed classic pathological features of CJD.Conclusion On the base of typical clinic manifestations, EEG and DWI examinations are useful in early diagnosis of sporadic CJD.
出处
《临床神经病学杂志》
CAS
北大核心
2005年第1期4-6,共3页
Journal of Clinical Neurology