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Bcl-2蛋白的小分子抑制剂 被引量:1

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摘要 Bcl 2蛋白家族在调节细胞凋亡中发挥重要作用 ,人类恶性肿瘤细胞高表达Bcl 2和Bcl XL ,而高表达这些抗凋亡分子的细胞对于化疗药物有抗性 ,因此 ,以Bcl 2家族蛋白为靶点的小分子抑制剂成为很有潜力的可用于多种肿瘤治疗的药物 ,通过下调Bcl 2和Bcl XL的表达直接影响肿瘤细胞的存活及其对化疗药物的抗性。
作者 李杨
出处 《国外医学(药学分册)》 2005年第1期10-13,共4页 Foreign Medical Sciences(Section of Pharmarcy)
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