摘要
①目的 探讨静脉浸润胃癌CD4 4v6 ,蛋白激酶C(PKC)及增殖细胞核抗原 (PCNA)高表达与肝转移的关系。②方法 用免疫组化染色SABC法检查并分析 2 8例静脉浸润胃癌CD4 4v6 ,PKC及PCNA高表达与肝转移的关系。③结果 2 8例静脉浸润的胃癌病人中有 14例发生肝转移。有无肝转移两组间CD4 4v6及PKC的表达有显著性差异 (P =0 .0 2 0 ,0 .0 2 0 ) ,PCNA的表达有极显著性差异 (P =0 .0 0 1)。④结论 胃癌细胞进入静脉仅仅是肝转移的一个解剖学基础 ,胃癌组织中出现了黏附分子、信号传导及细胞增生等复杂改变者易发生肝转移。
Objective\ To investigate the relationship between overexpression of CD44v6, PKC, and PCNA in gastric cancer with venous invasion and liver metastasis.\ Methods\ The paraffin embedded sections from 28 cases of gastric cancer with venous invasion were tested by SABC immunohistochemical technique for overexpression of CD44v6, PKC, and PCNA genes. The relationship between overexpression of CD44v6, PKC, and PCNA gene and liver metastasis was analyzed.\ Results\ 14 out of 28 cases of venous invasive gastric cancer had liver metastasis. There was a significant correlation between liver metastasis and CD44v6, PKC overexpression (P =0.020, 0.020), and PCNA expression was most significant ( P =0.001).\ Conclusion\ The fact that gastric cancer cells migrated into veins is just a anatomic basis for liver metastasis . The overexpression of CD44v6, PKC, and PCNA genes in patients with gastric cancer tends to liver metastasis.
出处
《青岛大学医学院学报》
CAS
2002年第2期149-150,共2页
Acta Academiae Medicinae Qingdao Universitatis
