摘要
目的:观察褪黑素对体外培养的大鼠胚胎中脑多巴胺能神经元存活率的影响。方法:取孕龄14d大鼠胚胎中 脑多巴胺能神经元细胞体外培养,加入10-10～10-5M的褪黑素,24h后观察存活细胞数。结果在褪黑素浓度为 10-5～10-8M时,存活细胞数明显多于对照组,差异具有显著性。结论:褪黑素对多巴胺能神经元具有保护作用。
Objectives:To observe the influence of melatonin on survival of rat embryonic midbrain's dopaminergic cells in vitro.Methods:The 14 days old rat embryonic midbrain's cells were cultured,with different concentration of melatonin ranging from 10 -10M to 10 -5M.After 24 hours,the number of survival cells was counted.Results:The number of survival cells were obviously more than that in control group when the concentration of melatonin was between 10 -5~10 -8M with a significant difference. Conclusion:melatonin has protective effects on dopaminergic cells.
出处
《实用临床医学（江西）》
CAS
2005年第2期1-3,6,共4页
Practical Clinical Medicine
