纳洛酮对创伤性休克家兔血管活性物质动态变化的影响

Effect of naloxone on dynamic changes of vasoactive substance in plasma on traumatic shock in rats

目的探讨家兔创伤性休克过程中血管活性物质的变化、意义及纳洛酮的抗休克作用。方法采用Lamson's法建立家兔创伤性休克模型。随机分为对照组和治疗组。观察两组家兔创伤性休克前、休克末及复苏后1h、3h、5h、12h血浆的一氧化氮(NO)、内皮素(ET)、神经肽Y(NPY)和心钠素(ANP)动态变化,并监测各时间点平均动脉压(MAP)变化。结果两组血浆一氧化氮、内皮素、神经肽Y、心钠素休克末、复苏后较休克前比较具有显著性差异(P<0.001),治疗组与对照组比较差异显著,治疗组明显低于对照组。复苏后治疗组MAP明显高于对照组(P<0.01)。结论休克时血浆一氧化氮、内皮素、神经肽Y、心钠素表达上调,纳洛酮可降低一氧化氮、内皮素、神经肽Y、心钠素浓度。

Objective To investigate the changes and significance of vasoactive substance and probe role of antishock of naloxone on traumatic shock in rats. Methods The traumatic shock model wa established applying Lamson's method.Being divided at random into control group and treatment group.The dynamic changes of MAP and plasma NO?ET?NPY?ANP levels have been detected before shock,at end of shock and in 1h?3h?5h?12h after resuscitation. Results The changes of plasma NO?ET?NPY?ANP levels of both groups were statistically significant after shock and resuscitation(P<0.01).Plasma NO?ET?NPY?ANP concentration at end of traumatic shock and after resuscitation were significantly lower in the treatment group than in the control group(P<0.01).MAP levels were significantly higher in the treatment group than in the control group. Conclusions The plasma NO?ET?NPY?ANP levels have been up regulated on traumatic shock.Naloxone can decrease the plasma NO?ET?NPY?ANP levels.