血清碱性成纤维细胞生长因子检测在急性淋巴细胞白血病中的临床意义

Determination of bFGF in Acute Lymphocyte Leukemia before and after Treatment

目的 探讨急性淋巴细胞白血病 (ALL)患者血清碱性成纤维细胞生长因子 (bFGF)水平及其临床意义。方法 应用酶联免疫法(ELISA)检测 26例ALL初发未治患者及 5例复发患者化疗前后血清bFGF的水平,并与正常对照组比较。结果 ALL初治患者血清bF GF水平为 (64. 71±27. 45 )pg/L,复发患者血清bFGF水平为 ( 76. 02±27 07 )pg/L,均明显高于正常人对照组水平 ( 24 06±5. 97 )pg/L,差异有非常显著性意义 (P<0. 001, 0. 05 );化疗后完全缓解 (CR)患者血清bFGF水平 [ (29. 64 ±7. 02 )pg/L]明显下降,与对照组相比无显著性差异 (P>0 05 ),经化疗无效 (NR)患者血清bFGF水平 [ 76. 16±29. 83 )pg/L]与化疗前水平 [ ( 82. 11±32. 64 )pg/L]相比无显著性差异 (P>0. 05 );NR组化疗前血清bFGF水平明显高于CR组化疗前的水平 [ 50. 36±12. 52 )pg/L],P<0. 01。结论 ALL患者存在bFGF的异常高表达,检测血清bFGF对ALL的疗效观察和预后判断有一定临床价值。

Objective To study the serum level of basic fibroblast growth factor (bFGF) and its clinical significance in acute lymphocyte leukemia (ALL). Methods Serum levels of bFGF were measured before and after treatment in patients with ALL by ELISA, and compared with that of normal controls.Results Serum levels of bFGF in the patients with ALL before treatment \ and in the patients with relapse \ were significantly higher than that \ in normal controls (P<0.05, P<0.001). Serum levels of bFGF of complete remission (CR) patients \ decreased so significantly that there was no clear difference between CR group and normal group (P>0.05). Serum bFGF levels of non- remission (NR) group before and after treatment respectively were (82. 11±32.64)pg/L and (76.16±29.83)pg/L, and the difference between them was not significant (P>0.05). Serum bFGF levels of NR group was obviously higher than that of CR group \ before treatment (P<0.01).Conclusion It is showed that bFGF is over expressed in ALL patients, and its serum level is a useful item for both detecting the effect of treatment and predicting the prognosis of ALL patients.