2-芳酰氨基-5-(5-甲基异(口恶)唑-3-基)-1,3,4-噻二唑及3-(5-甲基异(口恶)唑3-基)-4-芳酰基-1,2,4-三唑啉-5-硫酮的合成

SYNTHESIS OF 2-AROYLAMlNO-5-(5-METHYLISOXAZOLE-3-YL)-1,3,4-THIADIAZOLES AND 3-(5-METHYLISOXAZOLE-3-YL)-4-AROYL-l, 2,4-TRIAZOLINE-5-THIONES.

用I-(5-甲基异(口恶)唑-3-甲酰基)-4-芳酰基氨基硫脲I在酸或碱催化下合成8种2-芳酰氨基-5-(5-甲基异(口恶)唑-3-基)-1,3,4-噻二唑类衍生物Ⅱ(1—8)和8种3-(5-甲基异(口恶)唑-3-基)-4-芳酰基1.2.4-三唑啉-5-硫酮衍生物Ⅲ(1—8).Ⅱ和Ⅲ均经元素分析,IR,H-NMR和MS分析确定其结构.

The derivatives of eight new 2-aroylamino-.cv(5 methylisoxazol-3-yl)-1 , 3. 4-thiadiazoles I ,_8 and eight 3-(5-methylisoxazole-3-yI )-<1-aroyl-1, 2, <1-triazoline-5-thiones n ,_?are synthesized from the key inferniediate l-(5-meth-ylisoxazole-3-carbonyl )-<1-aroylthiosemi carbazides I through cafa-lyst of acid or alkaline mediate. Their structures, are determinated by the elemental analysis, IR, H-NMR and MS.