摘要
目的探讨奥沙利铂联合大剂量亚叶酸钙与氟尿嘧啶治疗晚期胃癌的疗效及其安全性。方法晚期胃癌患者45例,采用奥沙利铂联合大剂量亚叶酸钙及氟尿嘧啶治疗,疗程3周期。结果部分缓解18例,无变化17例,进展10例,总有效率40.0%。中位疾病进展时间5个月,1年生存率58.7%。毒性反应主要为感觉神经毒性(54.3%),其次为恶心、呕吐和腹泻;骨髓抑制毒性小。结论奥沙利铂联合大剂量亚叶酸钙与氟尿嘧啶方案治疗晚期胃癌,疗效肯定,患者耐受性较好。
Objective To observe the therapeutic effect and safety of axaliplatin combination with fluorouracil/high-dose folic acid calcium in advanced gastric cancer.Methods 45 patients with advanced gastric cancer were treated by axaliplatin combination with fluorouracil/high-dose folic acid calciums for 3 courses.Results There were 18 cases with partial responses,17 cases with stable diseases,10 cases with progressive disease.The total effective rate was 40.0%.The median time to progress was 5 months.1-year survival rate was 58.7%.The main toxicity was neuropenia (54.3%),followed by nausea,vomiting and diarrhea.Bone marrow suppression was mild.Conclusion The therapeutic effect of axaliplatin combination with fluorouracil/high-dose folic acid calcium in advanced gastric cancer is assured,with good tolerance.
出处
《中国综合临床》
北大核心
2005年第3期243-244,共2页
Clinical Medicine of China
关键词
胃癌
奥沙利铂
亚叶酸钙
氟尿嘧啶
Gastric tumor
Axaliplatin
Folic acid
Fluorouracil
