蛋白C抗凝系统在肾病综合征中的变化

Clinic Significantial and Changing of Protein C System in Nephropathy Syndrome

目的探讨血浆蛋白C(PC)抗凝系统在肾病综合征(NS)患者中的变化及临床意义。方法采用ELISA 法测定20例NS患者,24例慢性'肾功不全患者及30例正常对照组血浆PC抗原、血浆游离蛋白S(FPS)及血浆总蛋白S (TPS)含量,并用凝固法测定血浆蛋白S(PS)活性。结果NS患者PC抗原含量高于正常对照组(P<0.05)。TPS含量与正常对照组基本一样(P>0.05),而FPS含量及PS活性均明显低于正常对照组(P<0.05)。肾功不全患者除FPS含量低于正常对照组外(P<0.05),其他各项指标都与正常对照结果基本一样(P>0.05))。结论NS患者PC含量增高,这可能与机体代偿性合成增加以及机体对高凝状态的代偿性反应有关,有缓解NS高凝状态的作用。而FPS含量及PS活性降低,可能导致NS的高凝状态加重,可能是血栓形成的危险因素之一。

Objective To investigate the clinic sigificantial and changing of protein C ( PC) system in patients with nephropathy syndrome ( NS). Methods The plasma levels of PC antigen, total and free protein S antigen(TPS and FPS)in 20 patients with NS,24 patients with chronic renal failure and 30 normal controls were measured by ELISA method. The functions levels of protein S( PS) were measured by coagulant method. Results Patients with NS had a higher levels of PC antigen compare with the normal controls ( P < 0. 05 ) . But they had a lower levels of FPS antigen and the functions levels of PS compare with the normal controls (P < 0. 05). The TPS had no evidence difference to the normal controls ( P > 0. 05 ). The patients with chronic renal insufficiency,except the levels of FPS were lower than normal controls,the others had no evidence difference compare with the normal controls ( P > 0. 05 ) . Comclusion The levels of PC antigen in patients with nephropathy syndrome were higher than the normal control. It may be relevant to compatray synthetic increase of body and the respond to hypercoagulability. It can reduce the hypercoagulability. The defects of levels of FPS antigen and the functions levels of PS activity maybe increase the hypercoagulability it is a rist factor of thromboembolic complications.