白细胞介素1α、4、6、TNF-α基因多态性与桥本甲状腺炎的关系

Association of interleukin-1α, 4, 6, TNF-α gene polymorphisms with Hashimoto′s thyroiditis

对中国山东地区汉族人群白细胞介素 (IL) 1α、IL 4、IL 6、TNF α基因多态性与桥本甲状腺炎(HT)的关联性进行研究。结果显示 ,HT组IL 4启动子区 (-5 90 )位置t等位基因频率明显低于对照组(0 .0 60vs 0 .15 5 ,P <0 .0 5 ) ,HT组IL 4(-5 90 )c/t杂合基因型频率显著低于对照组 (0 .10 0vs 0 .2 5 0 ,P<0 .0 5 ) ,HT组IL 1α、IL 6、TNF α基因多态性与对照组比较差异无显著性。

The association of the polymorphisms of interleukin (IL)-1α, IL-4, IL-6, tumor necrosis factor-α (TNF-α) gene with Hashimoto′s thyroiditis (HT) in Shandong population of China was investigated. The results showed that the frequency of the t allele in the promoter region of IL-4 at position -590 in HT group was significantly lower than that in control group (0.060 vs 0.155, P<0.05), the frequency of IL-4 (-590) c/t heterozygote genotype in HT group was significantly lower than that in control group (0.100 vs 0.250, P<0.05), and there were no significant differences between HT group and control group for IL-1α, IL-6, TNF-α gene polymorphisms.