血浆D-二聚体和纤维蛋白原含量与恶性肿瘤相关性分析

The Interrelation Between Maiignancy and Levels of Plasma D-dimer and Fibrinogen

目的:探讨血浆D-二聚体(D- dimer)和纤维蛋白原(Fg)含量与恶性肿瘤的相关性及观察二者水平变化与疗效及预后的关系。方法:取32 0例5种常见恶性肿瘤患者和30例对照组(健康体检者)的静脉血,采用乳胶凝集半定量法测定血浆D- dimer,采用半自动血凝仪检测Fg含量。结果:32 0例恶性肿瘤患者中,肿瘤初治组和难治转移组的血浆D- dimer及Fg含量明显升高,治疗缓解组血浆D- dim er及Fg含量有不同程度下降。结论:D- dimer及Fg含量变化与原发性肝癌、直肠癌、胃癌、肺癌、乳腺癌的病情严重程度及预后显著相关。其检测方法简便、快速、敏感性高。

Objective To observe the relationship of malignant patient,plasma D-dimer and fibrinogen.Methods measure plasma D-dimer and fibrinogen levels of 320 tumor patient and 30 normal adult,Measure plasma D-dimer levels was using Latex Agglutinative test(LAT).measure plasmafibrinogen 1evels was using semiautomatic coagulometer.Results Plasma D-dimer and fibrinogen levels in the primary therapy group were higher than the normal adult group.Plasma D-dimer and fibrinogen 1evels in the catabatic group were downtrend.Conclusions Measure plasma D-dimer andfibrinogen levels may be a prediCtor in tumor patient.