情感障碍和精神分裂症的遗传调查与分析

Comparison of gentic history between affective disorder and schizophrenia.

目的 探讨情感障碍和精神分裂症的遗传学差异。方法 收集首次住我院并符合CCMD - 3诊断标准的情感障碍及精神分裂症病例 ,以有无家族史按诊断分组对照分析。结果 同类疾病比较 ,女性情感障碍家族史阳性率高于男性情感障碍家族史阳性率 ,女性精神分裂症家族史阳性率高于男性精神分裂症家族史阳性率。同性别不同疾病比较 ,即男性精神分裂症与男性情感障碍比较 ,女性精神分裂症与女性情感障碍比较 ,仅见女性精神分裂症家族史阳性率高于女性情感障碍家族史阳性率。另外 ,还发现不论是精神分裂症还是情感障碍 ,均见Ⅰ级亲属家族史阳性率高于Ⅱ级 ,Ⅱ级高于Ⅲ级。结论 遗传因素是情感障碍和精神分裂症发病的重要因素之一 ,且患病基因可能位于X染色体上。

Objective To compare the gentic history be tween affective disorder and schizophrenia.Method 1561 sc hizophrenic patients and 613 affective disorder patients at first hospitalizatio n diagnosed according to CCMD-3 and followed up were divided into different grou ps by family history.Results For the same disease,the rat e of positive family history in female patients was much higher than that in mal e patients;for the same sex,it was only found the rate of positive family histor y in female schizophrenic patients was much higher than that in female affective disorder patients,and in both schizophrenic patients and affective disorder pat ients,the rate of positive family history in first relative was much higher than that in second relative,the rate of positive family history in second relative was much higher than that in third relative.Conclusion Ge ntic factor is one of the main onset effects in schizophrenia and affective diso rder,and disease gene may be on X-chromatin.