难辨梭状芽孢杆菌性肠炎28例临床分析

Clinical analysis in 28 patients with clostridium difficile colitis

目的 了解加强监护病房 (ICU)难辨梭状芽孢杆菌性肠炎 (CDAD)危险因素、症状及疗效。方法 选取1999～ 2 0 0 3年大便难辨梭状芽孢杆菌培养阳性患者 2 8例及治疗观察临床表现。结果 腹泻 2 8例 (10 0 % ) ,发热2 8例 (10 0 % ) ,腹痛 2 0例 (71 4 % )。结论 用抗生素过程中出现腹泻应首先怀疑难辨梭状芽孢杆菌性肠炎 ,行粪便难辨梭状芽孢杆菌培养 ,有条件应进行毒素A、B检测 ,尽早治疗。

Objectiue:To study the incidence, dangerous factors of clinical symptoms, curative effect in intensive care unit (ICU). Methods: 28 patientswith positively cultured clostridium difficile were selected for treatment and observation of clinical symptoms.Results:Diarrhea occurred in 28 cases (100%), fevers in 28(100%) and stomachache in 20(71.4%).Conclusion:If diarrhea occurs in the patients during the use of antibiotics, clostridinm difficile colitisshould be considered and cultured clostridium difficile tests be done for toxin A or B and special treatment.