鼻咽癌组织中β-连环蛋白基因表达水平的初步研究

Gene expression of beta-catenin in human nasopharyngeal carcinoma

目的 观察鼻咽癌组织中β 连环蛋白 (β catenin)的基因表达水平 ,以进一步研究其与鼻咽癌发生、发展的关系。方法 采用RT PCR半定量方法检测鼻咽癌组织及正常鼻咽组织中β 连环蛋白的表达情况。结果 15例鼻咽癌组织中有 11例β 连环蛋白基因表达水平减弱 (占 73 3% )。结论 β 连环蛋白的异常表达在一定程度上改变了鼻咽癌组织的分子正常功能及其介导的信号传导作用 ,提示β 连环蛋白是一个与鼻咽癌的发生、发展相关的生物学指标。

Objective To investigate the relationship between β-catenin gene expression and the mechanism of tumorigenesis, development and metastasis of human nasopharyngeal carcinoma. Methods RT-PCR method was used to detect the mRNA expression of β-catenin in normal human nasopharyngeal tissues and nasopharyngeal carcinoma. Results The results showed that β-catenin expression in 11 out of 15 nasopharyngeal carcinoma specimens was decreased (73.3%). Conclusion The abnormal expression of β-catenin changed in the normal adhesive function and the signal transduction pathway of the cell in human nasopharyngeal carcinoma, indicating that the expression level of β-catenin was a biological marker of tumorigenesis and development of human nasopharyngeal carcinoma.