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不动杆菌耐碳青霉烯类抗生素机制的研究进展 被引量：2

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摘要 碳青霉烯类(Carbapenem)抗生素属于β-内酰胺类抗生素，是迄今为止开发的抗菌药物中抗菌谱最广、抗菌作用最强的一类抗生素。由于该类药物对β-内酰胺酶高度稳定，包括耐三代头孢菌素的超广谱β-内酰胺酶(ESBLs)及头孢菌素酶(如AmpC酶)，而且本身又具有抑酶作用，因而具有广谱、强效、耐酶、抑酶等诸多优点。已上市的碳青霉烯类抗生素有亚胺培南／西司他丁、美洛培南、帕尼培南、法罗培南。
作者 何崇旻 葛庚芝
机构地区 天津医科大学第二医院
出处 《中国医学文摘（内科学）》 2005年第1期121-123,共3页 China Medical Abstracts
关键词 碳青霉烯类抗生素 不动杆菌 美洛培南 头孢菌素酶 ESBL 法罗培南 帕尼培南 机制 优点 高度
分类号 R978 [医药卫生—药品] R378 [医药卫生—病原生物学]
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二级参考文献62

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  • 3Yah J, Hsueh P, Ko W, et al. Metallo-beta-lactamase in clinical Psedumonas isolates in Taiwan and identification d VIM-3, a novel variant of VIM-2 enzyme. Antimicrob Agents Chemother, 2001,45 :2224-2228.
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共引文献94

同被引文献16

  • 1耿治英,吴大玮.不动杆菌耐碳青霉烯类抗生素机制的研究进展[J].国外医药（抗生素分册）,2005,26(4):184-189. 被引量：8
  • 2Guenthner SH, Hendly JO, Wenzel RP. Gram-negative bacilli as nontransient flora on the hands of hospital personnel [J]. J Clin Microbial, 1987, 25 (3) : 488 -490.
  • 3CISI. Performance standards for antimicrobial susceptibility testing (Seventeenth Informational Supplement). Wayne, PA, USA: Clinical and Laboratory Standards Insititute, 2007, 27 (3): 33-34.
  • 4Livermore DM, Woodford N. Carbapenemases: a problem in waiting? [J]. Curr Opin Microbiol, 2000, 3 (5) : 489- 495.
  • 5Lu Po-Liang, Huang Li Yueh, Lian Shen-Tsuen, et al. How carbapenem-resistant Acinetobacter spp. established in a newly constructed hospital [ J ]. Int J Antimicrob Agents, 2008, 31 (5) : 463 - 466.
  • 6Marque S, Poirel L, Heritier C, et al. Regional occurrence of plasmidmediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe [ J ]. J Clin Microbiol, 2005, 43 (9) : 4885 -4888.
  • 7Perez F, Hujer AM, Decker BK, et al. Global challenge of multidrug-resistant Acinetobacter baumannii [ J ]. Antimicrob Agents Chemother, 2007, 51 (10) : 3471 -3484.
  • 8Peter EDJ, Leverstein-van MA, Box ATA, et al. Novel gene cassettes and integrons [ J ]. Antimicrob Agents Chemother, 2001,45(10) : 2961 -2964.
  • 9李家泰.临床药理学[M]北京:人民卫生出版社,2001636.
  • 10Lee K,Lim YS,Yong D. Evaluation of the hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp and Acinetobacter spp[J].Journal of Clinical Microbiology,2003,(10):4623.

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二级引证文献5

中国医学文摘（内科学）
2005年 第1期

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