西沙必利在腹膜氧合治疗急性肺损伤中对血气的影响

The Effect of Cisapride on Blood Gas in the Peritoneal Oxygenation Therapy in Acute Lung Injury

目的 探讨西沙必利在腹膜氧合治疗急性肺损伤的过程中,对血气的变化及其可能机制。方法 24只家 兔经油酸诱发急性肺损伤模型后,随机分为腹膜氧合组(A组)、腹膜氧合西沙必利组(B组)和非腹膜氧合西沙必 利组(C组),每组8只,各组在急性肺损伤出现后,观察治疗1、2、4h动脉血气变化。结果 A、B组治疗后各时点 动脉血氧分压(PaO2)进行性升高,C组治疗后各时点动脉血氧分压升高不明显。治疗后1hB组的PaO2明显高于 A、C两组(P<0.05),而A、C两组间无统计意义(P>0.05);在治疗后2、4h两个时点,A、B、C三组间的PaO2均 有显著差异(P<0.05),其中以B组的PaO2最高,A组次之。动脉血二氧化碳分压(PaCO2)各组间没有显著差异 (P>0.05)。结论 在经腹膜氧合治疗急性肺损伤过程中,西沙必利可能通过增加内脏血液循环进一步促进腹膜 氧合的效果,因而可作为腹膜氧合中有益的辅助药物。

Objective To explore the effect and mechanism of cisapride in peritoneal oxygenation therapy in acute lung injury.Methods After acute lung injury was induced in adult rabbit with oleic acid,twenty-four rabbits were randomly divided into three groups(n=8,each) and received:peritoneal oxygenation without cisapride group(group A);peritoneal oxygenation with cisapride group(group B)and non-peritoneal oxygenation with cisapride group(group C).The changes of blood gas;heart rate(HR);mean artery pressure(MAP)were observed after acute lung injury was induced and treatment was commenced at 1,2,4 hours.Results PaO 2 in group A and group B was obviously increased,while it was slightly increased in group C.Extraordinarily,at 2 and 4 hours after treatment,compared with group A and group C ,PaO 2 was remarkably increased in group B(P<0.01).PaCO 2 was no significant difference between each other group at 4 hours after treatment.Conclusion Cisapride increases arterial oxygenation farther in rabbits with acute lung injury treated with peritoneal oxygenation,probably due to its ability to increase splanchnic circulation. It should be considered as an adjuvant medication to peritoneal oxygenation.