静脉吸毒人群经血传播疾病的感染调查

Infection of Diseases Transmitted Through Blood of Venous Drug Addicts

目的 了解温州地区静脉吸毒者经血传播疾病的感染情况。方法 采集静脉吸毒者血液标本 ,分离血清 ,用半巢式PCR检测TTV ,用ELISA检测抗 -HCV、HBsAg、抗 -HBs、HBeAg、抗 -HBe、抗 -HBc等。 结果 共检测 30 6例 ,TTV、抗 -HCV、HBsAg、抗 -HBs、HBeAg、抗 -HBe、抗 -HBc的阳性率分别为 7 5 2 %、4 2 4 8%、19 6 1%、4 4 12 %、7 19%、7 84 %和 4 1 5 0 %。乙肝五项标志物中一项或以上阳性者 2 2 6例 ,感染率为73 86 %。HCV、TTV和HBV同时检出率高。吸毒者不同血型的TTV、HCV、HBV感染率无显著差异。结论 静脉吸毒者是经血传播疾病的高危人群 ,几种疾病可同时或重叠感染 ;共有未经灭菌的注射器可造成交叉感染 ,可能是吸毒者感染这些疾病的主要原因。故应采取控制措施 ,降低吸毒人群感染这些疾病的频率。

Objective To explore the infection status of diseases transmitted through blood of venous drug addicts in Wenzhou City. Methods Collecting blood sample of venous addicts to separate serum and test TTV by using semi-nidi PCR; Using ELISA to test anti-HCV, HBsAg,anti-HBs, HBeAg, anti-HBe, anti-HBc, etc. Results Total of 306 cases were tested, the positive rates of TTV, anti-HCV, HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 7.52%, 42.48%,19.61%,44.12%,7.19%,7.84% and 41.5%, respectively. There were 226 cases with one or more than one positive of the five indicators of Hepatitis B, and the positive rate was 73.86%. The concurrent positive rate of HCV, TTV and HBV was high, and there was no remarkablely difference for TTV, HCV and HBV infection rate of different blood types of drug addicts. Conclusions The venous drug addicts were high-risk population for diseases transmitted through blood , several diseases could come thogether or overlap one another for these people. Joint use of non-disinfected syringe could bring cross infection, maybe it was the main cause for drug addicts catching these diseases. So control measures should be taken to reduce the frequency of diseases infection among drug addicts.