RTNs家族研究进展

Progress in RTNs Family

编码内质网蛋白家族的基因(RTNs)是一类广泛存在于真核生物的基因家族,它有着特殊的拓扑结构。RTNs蛋白的羧基端存在一个大约200个氨基酸的保守区(RHD),此保守区包含2个疏水区段。RTNs蛋白定位内质网膜上,高等脊椎动物中枢神经受损时,RTN4-A/Nogo-A起抑制神经生长的作用,RTNs蛋白家族其余成员的功能还不是很清楚,可能与胞内运输,细胞分裂和细胞凋亡等有关。现就RTNs成员的基本结构、表达分布、亚细胞定位、拓扑结构和RTNs蛋白的功能等进行综述。

Reticulons (RTNs) were an eukaryotic gene family with peculiar topological features and broadexpressions. RTNs were characterized by a ~200-amino-acid C-terminal domain, including two long hydrophobicsequences. RTNs functions might relate to those of the endoplasmic reticulum for example, intracellular trafficking,cell division and apoptosis. Nogo/RTN4-A could inhibit neurite growth from the cell surface via specific receptors.Here, we reviewed the basic structure, the taxonomic distribution and tissue expression of RTNs, summarizedrecent discoveries about RTNs localization and membrane topology, and discussed the possible functions of RTNs.