CD4^+CD25^+调节性T细胞

CD4^+CD25^+ Regulatory T Cells

调节性T细胞(regulatory T cells, Treg)是机体维持自身耐受的重要组成部分。CD4+CD25+ Treg细胞来源于胸腺,其主要功能是抑制自身反应性T细胞,并且其作用是通过直接的Treg-T效应细胞之间的相互接触方式来实现的。CD4+CD25+ Treg细胞可分泌多种抑制性细胞因子,但与其抑制功能关系并不明确,目前有证据表明GITR和Foxp3与CD4+CD25+ Treg细胞的抑制功能有关,并且Foxp3已作为CD4+CD25+ Treg细胞的特异性标志。通过IL-10、TGF-b等抑制性细胞因子、imDC以及转基因技术可以产生具有免疫抑制功能的调节性T细胞。调节性T细胞在免疫相关性疾病、肿瘤免疫和抗感染免疫等方面具有重要意义。

Thymus derived CD4+CD25+ regulatory T cells (Treg) were critical for the inhibition ofautoreactive T cells and play a crucial role in maintaining self-tolerance. These cells mediated their suppressiveeffects by direct cell to cell contact-dependent, without the requirement of immunosuppressive cytokines. Therewere more evidences that the transcription factor Foxp3 acted as the master control gene for Treg that definedthis subset as a distinct T cell lineage. Regulatory T cells were produced by immunosuppressive cytokines, such asinterleukin-10 or TGF-b, and immature dendritic cells. A better understanding of the role of regulatory T cells inautoimmunity and anti-tumor immunity may lead to the identification of novel therapeutic targets.