小梁切除术联合鸦胆子治疗青光眼临床观察

A clinical investigation on filtration surgery with khosam kernel for treatment of glaucoma

目的 :观察滤过手术联合鸦胆子治疗难治性青光眼的疗效。方法 :将 36例 ( 4 4只眼 )难治性青光眼随机配对分为鸦胆子治疗组 2 2只眼与丝裂霉素 (MMC)对照组 2 2只眼。一组在常规小梁切除术中辅助用 3～ 5mg鸦胆子仁 ,另组在术中使用0 .1mg/MMC ,术后随访 1年。 结果 :鸦胆子治疗组手术成功率为 95.4 5% ( 2 1/2 2 ) ,MMC对照组为 81.82 % ( 18/2 2 ) ,P <0 .0 5。功能性滤过泡眼数 ,鸦胆子治疗组为 19/2 2 ,MMC对照组为 18/2 2 ,治疗组未见全身和局部副作用。结论 :鸦胆子能促进滤过泡的形成 ,提高青光眼滤过手术的成功率 ,效果优于丝裂霉素。

objective:To observe the therapeutic effects of filtration surgery with khosam in treatment of glaucoma with poor prognosis. Methods: Method 36 palients (44 eyes) were randomly divided into two groups 22 eyes in khosam groups and 22 eyes in group. One group was used khosam kernel 3～5mg, the other group used mitomycin 0.1mg/ml, all of the patients had successful decresse in I-OP 1 year after surgery than before surgery the posto-erative follow-up period ranged from 1 year. Results: The successful rate of operation of khosam group was 95.45% and that of the control group, 81.82% (P<0.05). The rate of eyes with functional filtering blebs was 19/22 and that of the control group, 18/22(P>0.05). There were no significant. Side-effect in khosam group. Conclusions: The results show that khosam can promote the formation of functional filtering bleb and elevate the successful rate of filtration surgery.