期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞角蛋白检测在非小细胞肺癌骨髓和淋巴结微转移中的意义 被引量：1

Importance of cytokeratine detection for micrometastatic tumor cells in bone marrow and lymph node in patients with non-small lung cancer
下载PDF
导出
摘要 癌细胞的微转移是非小细胞肺癌重要的问题 ,骨髓和淋巴结是主要转移部位 ,细胞角蛋白作为检测骨髓和淋巴结的肺癌早期微转移灶的重要参数 ,在评估肺癌病人的预后中具有重要意义。 Tumor cell micrometastasis is a very important problem in non-small lung cancer.Bone marrow and lymph nodes are the major metastatic organs. Detection of cytokeratin is an important parameter of early stage micrometastasis to bone mallow and lymph node in patients of non-small cell lung cancer,and it is of very important significance on prognosis in patients with lung cancer.
作者 朱莲妹 万欢英
机构地区 上海第二医科大学瑞金医院肺科
出处 《上海第二医科大学学报》 CSCD 2004年第12期1067-1069,共3页 Acta Universitatis Medicinalis Secondae Shanghai
关键词 骨髓 细胞角蛋白 非小细胞肺癌 淋巴结微转移 微转移灶 病人 早期 重要意义 参数 部位 cytokeratin non-small lung cancer bone marrow lymph node micrometastasis
分类号 R734.2 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1Cote RJ, Beattie EJ,Chaiwun B, et al. Detection of occult bone marrow micrometastases in patients with operable lung carcinoma[J]. Ann Surg,1995,222: 415 - 425.
  • 2Ohgami A, Mitsodomi T,Sugio K,et al. Micrometastatic tumor cells in the bone marrow of patients with non-small cell lung cancer [J].Ann Thorac Surg, 1997,64: 363 - 367.
  • 3Pantel K,Izbicki JR,Passlick B,et al. Frequency and prognostic significance of isolated tumor cells detected in bone marrow of nonsmall cell lung cancer patients without overt metastases[J]. Lancet,1996,347: 649 - 653.
  • 4Passlick B, Izibicki JR, Kubuschok B, et al. Detection of disseminated lung cancer cells in lymph nodes: impact on staging and prognosis [ J]. Ann Thorac Surg,1996,61: 177 - 183.
  • 5Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage 1 lung cancer [ J].Thorac Cardiovase Surg,1995,109: 120 - 129.
  • 6Passlick B, Kubuschok B, Izbicki JR,et al. Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer [ J]. Ann Thorac Surg,1999,68:2 053 -2 058.
  • 7Osaki T, Oyama T, Inoue M, et al. Molecular biological markers and micrometastasis in resected non-small-cell lung cancer. Prognostic implications [ J ]. Jpn J Thorac Cardiovasc Surg, 2001,49(9): 545 -551.
  • 8Osaki T, Oyama T, Gu CD, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer [J]. J Clin Onco,2002,20(13): 2 930 -2 936.
  • 9Sugio K, Kase S, Sakada T,et al. Micrometastasis in the bone marrow of patients with lung cancer associated with a reduced expression of E-cadherin and beta-catenin: risk assessment by immunohistochemistry [ J]. Surgery ,2002,131 (suppl): 226 - 231.
  • 10Yasumoto K, Osaki T, Watanabe Y,et al. Prognostic value of cytokeratin-positive cells in the bone marrow and lymph nodes of patients with resected nonsmall cell lung cancer: a multicenter prospective study [ J]. Ann Thorac Surg,2003,76: 194 -201.

二级参考文献9

  • 1Bostick PJ,Chatterjee S,Chi DD,et al.Limitation of specific reversetranscriptase polymerase chain reaction markers in the detection of metastasis in the lymph nodes and blood of breast cancer patients[].Journal of Clinical Oncology.1998
  • 2Dobashi K,Sugio K,Osaki T,et al.Micrometastatic p53-positive cells in the lymph nodes of non-small-cell lung cancer: prognostic significance[].Journal of Thoracic and Cardiovascular Surgery.1997
  • 3Sasaki M,Watanabe H,Jass JR,et al.Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of Kras[].Histopathology.1998
  • 4Haboubi NY,Clark P,Kaftan SM,et al.The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal carcinoma[].Journal of the Royal Society of Medicine.1992
  • 5Moll R.Cytokeratins as markers of differentiation[].Progr Pathol.1993
  • 6Passlick B,Izbicki JR,Kubuschok B,et al.Immunohistoc-hemical assessment of individual tumor cells in lymph nodes of patients with nonsmall-cell lung cancer[].Journal of Clinical Oncology.1994
  • 7Hermanek P,Scheibe O,Spiessl B,et al.TNM classification of malignant tumors: the new 1987 edition[].Rontgen Blatter.1987
  • 8Izbicki JR,Passlick B,Hosch RB,et al.Mode of spead in the early phase of lymphatic metastasis in non-small-cell lung cancer: significance of ndal micrometastasis[].Journal of Thoracic and Cardiovascular Surgery.1996
  • 9Peto R,Pike MC,Armitage P,et al.Design and analysis of clinical trials requiring prolonged observation of each patient: analysis and examples[].British Journal of Cancer.1977

共引文献9

同被引文献7

  • 1狄方,王念黎.免疫组织化学标记物在乳腺细针吸取细胞学鉴别诊断中的意义[J].中华病理学杂志,2006,35(12):738-743. 被引量：17
  • 2Levy-lahad E, Plon SE. Cancer: a risky business-assessing breast cancer risk. Science, 2003, 302:574-575.
  • 3Dillon DA. Molecular markers in the diagnosis and staging of breast cancer. Semin Radiat Oncol, 2002,12:305-318.
  • 4Stathopoulou A, Mavroudis D, Perraki M, et al. Molecular detection of cancer cells in the peripheral blood of patients with breast cancer: comparison of CK-19, CEA and maspin as detection markers. Antieaneer Res, 2003,23:1883-1890.
  • 5Gal-Gombos EC, Esserman LE, Recine MA , et al. Large-needle core biopsy in atypical intraductal epithelial hyperplasia including immunohistochemical expression of high molecular weight cytokeratin analysis of results of a single institution. Breast J, 2002,8:269-274.
  • 6Oliai BR, Kahane H, Epstein JI. Can basal cells be seen in adenocarcinoma of the prostate? an immunohistochemical study using high molecular weight. Am J Surg Pathol, 2002,26 : 1151-1160.
  • 7Sturm N,Lantuejoul S, Laverriere M, et al. Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (CK.34βE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung. Hum Pathol,2001,32:918-925

引证文献1

二级引证文献1

上海第二医科大学学报
2004年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部