血液透析对尿毒症患者血清内皮素-1、一氧化氮、血管紧张素Ⅱ的影响及临床意义

Effect and Clinical Significance of Hemodialysis on Serum Nitric Oxide,Endothelin -1 and Angiotonin Ⅱ in Uremia Patients

目的:探讨血液透析对尿毒症患者血清内皮素-1(ET-1)、一氧化氮(NO)、血管紧张素Ⅱ(AngⅡ)的影响及临床意义。方法:用比色法测定血NO水平、用放射免疫法测定血ET-1、AngⅡ水平,同时设立对照组。结果:尿毒症患者血清NO、ET-1、AngⅡ水平明显高于正常对照组,P<0.001;经透析治疗的尿毒症患者与尿毒症未透析者比较,血清NO水平较未透析者低、血清ET-1、AngⅡ水平较未透析者高,P<0.05;结论:血液透析可以引起患者血清NO水平下降、ET-1、AngⅡ升高,尿毒症患者血液透析后的高血压可能与血NO浓度降低、血ET-1、AngⅡ浓度增高有一定的关系。

Objective: To investigate the effect and clinical significance of hemodialysis on serum Nitric oxide(NO), Endothe-lin - 1 (ET - 1) and Angiotonin Ⅱ (Ang Ⅱ ) in uremia patients. Methods: The NO serum level was detected by colorimetry and the levels of ET - 1 and Ang - Ⅱ were detected by radioimmunoassary (RIA), and compared with control groups. Results: The serum levels of NO, ET - 1 and Ang Ⅱin uremia patients were significantly higher than those in normal control group (P < 0.001). The levels of Ang Ⅱ and ET- 1 in uremia patients with hemodialysis therapy were higher than those without hemodialysis therapy (P < 0.05). The level of No in uremia patients with hemodialysis therapy were lower than those without hemodialysis therapy (P < 0.05). Conclusions: Hemodialysis can cause decline of serum NO and increase of serum ET - 1 and AngⅡin uremia patients , and Hypertention caused by hemodialysis is related with the decline of serum NO consistency and the raise of serum ET- 1 and Ang Ⅱconsistency.