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BRCA1和nm23-H1与乳腺癌预后的关系 被引量：1

The Relationship between Expression of BRCA1,nm23-H1 and prognosis in breast carcinoma
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摘要 目的 :探讨BRCA1、nm2 3 H1在乳腺癌预后中的作用及相互关系。方法 :对 10 6例乳腺癌患者的肿瘤组织石蜡切片采用免疫组织化学染色 (S P法 )技术标记BRCA1、nm2 3 H1。结果 :乳腺癌组织中BRCA1、nm2 3 H1蛋白表达明显降低 ,与生存期呈正相关 ,与复发呈负相关 (P <0 0 5 )。BRCA1与nm2 3 H1蛋白表达水平呈正相关 (P <0 0 5 )。结论 :BRCA1、nm2 3 H1在乳腺癌组织内共同参与癌组织的浸润和转移 。 Objective:To investigate the relationship of expression of BRCA1, nm23-H1 proteins with clinic biological behavior in breast cancer and its correlation.Methods:The expression of BRCA1, nm23-H1 proteins were investigated by immunohistochemistry in infiltrating breast cancer tissues.Results:The expressions of BRCA1, nm23-H1 were negative correlated with the recurrence, positive correlated with survival time (P<0.05). The expression of BRCA1 had positive correlation to that of nm23-H1(P<0.05).Conclusion:Both BRCA1 and nm23-H1 gene were involved in the development of breast cancer. BRCA1 and nm23-H1 expression, as a clinical valuable marker, has a great significance in assessing survival.
作者 李桂梅 张佃乾 王春淑 涂频
机构地区 解放军八一医院病理科
出处 《临床肿瘤学杂志》 CAS 2004年第6期601-603,607,共4页 Chinese Clinical Oncology
关键词 BRCA1 NM23-H1蛋白 乳腺癌组织 预后 S—P法 浸润和转移 免疫组织化学染色 患者 石蜡切片 生存期 Genes,BRCA1 nm23-H1 Tumor Breast neoplasms/pathology Immunohistochemistry Prognosis
分类号 R737 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献7

  • 1Yoshida H, Ki jima H, Terasaki Y, et al. Heterogenous expression of nm23 gene products a preditor of lymph nodal statua in human breast cancer[J]. Int J Oncol, 1998,13(6):1141-1146.
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二级参考文献20

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共引文献4

同被引文献24

  • 1胡震,吴炅,陆劲松,罗建民,韩企夏,沈镇宙,邵志敏.中国家族性和早发性乳腺癌BRCA1基因突变的研究[J].中华肿瘤杂志,2004,26(11):657-659. 被引量：11
  • 2杨举伦,史爱学,邹红,李涛,杨海捷,蔡琳.乳腺癌发生过程中p53、BRCA1、BRCA2、PTEN、Rb蛋白异常表达[J].临床与实验病理学杂志,2005,21(3):277-281. 被引量：9
  • 3王玉林,赵荣宇,张丽芝,关宏伟.BRCA1和BRCA2在乳腺疾病中的表达和意义[J].医师进修杂志（外科版）,2005,28(5):13-15. 被引量：11
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二级引证文献7

临床肿瘤学杂志
2004年 第6期

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