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牙源性角化囊肿与正角化牙源性囊肿CK10、Bcl-2免疫组化表达 被引量：2

Immunohistochemical Expression of CK10 and Bcl-2 in the Odontogenic Keratocyst and the Orthokeratinized Odontogenic Cyst
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摘要 目的 :比较牙源性角化囊肿 (odontogenickeratocyst,OKC)与正角化牙源性囊肿 (orthokeratinizedodonto geniccyst,OOC)中CK10及Bcl- 2的表达情况。方法 :OKC及OOC各 10例 ,分别行CK10、Bcl- 2免疫组化染色 ,并利用SPSS10 .0统计软件对免疫组化染色结果进行统计学处理。结果 :CK10在OKC中的阳性表达率为 80 % (8/10 ) ,而在OOC中为 10 0 % (10 / 10 ) (P >0 .0 5 )。OOC上皮中CK10阳性着色于除基底细胞层外的上皮全层 ,而OKC中CK10阳性着色仅见于上皮表层的不全角化层。Bcl- 2在OKC中的阳性表达率为 6 0 % (6 / 10 ) ,而在OOC中为 10 % (1/ 10 ) (P <0 .0 5 )。结论 :OKC与OOC的衬里上皮中免疫组化表达存在显著差别 ,OOC可能为有别于OKC的一种独立病损。 Objective: To compare the difference of the immunohistochemical expression between odontogenic keratocyst (OKC) and orthokeratinized odontogenic cyst (OOC). Methods: Ten cases of OKC and ten cases of OOC were stained with hematoxylin and eosin or immunostained with the monoclonal antibody against cytokeratin 10 and the monoclonal antibody against Bcl-2, and the results of immunostaining were analyzed by the statistical software SPSS 10.0 for Windows. Results: The positive stain of CK10 was seen in all suprabasal layers of OOC and in the superficial para-keratinized layer of OKC. The positive expression rate of cytokeratin 10 was 80 per cent (8/10) in OKC and 100 percent (10/10) in OOC (P>0.05), and the positive expression rate of Bcl-2 was 60 per cent (6/10) in OKC and 10 per cent (1/10) (P< 0.05) in OOC. Conclusion: The immunohistochemical expression of OKC is obviously different from that of OOC, and OOC can be regarded as an individual entity.
作者 彭利伟 赵怡芳 路彤彤
机构地区 武汉大学口腔医学院口腔颌面外科
出处 《口腔医学研究》 CAS CSCD 2004年第6期592-594,共3页 Journal of Oral Science Research
关键词 牙源性囊肿 牙源性角化囊肿 正角化牙源性囊肿 免疫组织化学 Odontogenic cyst Odontogenic keratocyst Orthokeratinized odontogenic cyst Immunohistochemistry
分类号 R782 [医药卫生—口腔医学]
  • 相关文献

参考文献10

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二级参考文献1

  • 1Tie-Jun Li,Roger M. Browne,John B. Matthews. Expression of epidermal growth factor receptors by odontogenic jaw cysts[J] 1993,Virchows Archiv A Pathological Anatomy and Histopathology(2):137～144

共引文献2

同被引文献14

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引证文献2

二级引证文献3

口腔医学研究
2004年 第6期

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