贺氏三通法对急性脑梗死患者血浆t-PA和PAI-1的影响

Effects of He's Santong Method on plasma t-PA and PAI-1 activities in the patient of acute cerebral infarction

目的 :探讨贺氏针法防治急性缺血性中风机理及其临床意义。方法 :将 50例急性脑梗死患者分为贺氏针法组 (观察组)和局部取穴组(常规组 )各 2 5例 ,分别观察针刺 2天、7天和 2 1天血浆组织型纤溶酶原激活物 (t PA)及快速抑制物 (PAI 1 )的活性 ,并与 2 0例脑梗死后遗症期住院患者(对照组 )进行对照。结果 :治疗后两组患者t PA活性降低又升高 (P <0 0 5)。观察组PAI 1活性升高又降低 ,与对照组比较差异无显著性意义 (P >0 0 5) ;常规组PAI 1活性降低又升高 ,且均明显高于对照组(P <0 0 5 ,P <0 0 1 )。结论 :贺氏针法对急性脑梗死患者血浆纤溶活性下降有一定的影响 。

Objective To explore the mechanism and clinical signifi ca nce of Hes needling method for treatment of acute ischemic apoplexy and pr event ion of thrombotic recurrence. Methods 50 cases of acute cerebral in f arction were divided into Hes needling method group (observation group) an d loca l point group (routine group), 25 cases in each group, and their plasma tissue t y pe plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) a ctivities were respectively investigated after acupuncture for 2, 7 and 21 days, w ith 20 inpatients of cerebral infarction at sequel stage used as control group. Results The t-PA activity on the second day of acute stage of cer ebral infarction decreased, and after treatment for 7 days the t-PA activities in both the observation group and the routine group increased (P<0 05). The PAI-1 activity on the 2nd day of acute stage increased and in the observation group on the 7th day decreased, with no significant difference compared with the control group (P>0 05); PAI-1 activity in the routine group on the 7th da y decreased and on the 21st day increased, which all were higher than those in t he control group (P<0 05,P<0 01). Conclusion Hes ne edlin g method can decrease plasma fibrinolytic activity in the patient of acute cereb ral infarction, and possibly has preventive action on recurrence of cerebral inf arction to a certain extent.