^(60)Co照射对大鼠舌菌状乳头及味蕾的影响

Changes of Taste Bud and Fungiform Papillae after^(60)Co Radiation in Rat

目的 研究临床治疗剂量6 0 Co照射头颈部恶性肿瘤后 ,舌菌状乳头及其味蕾的形态学变化和再生能力。方法 模拟临床治疗剂量 ,根据多次照射剂量归一的原则 ,一次大剂量6 0 Co照射 30只SD大鼠头颈部 ,照射后观察大鼠舌菌状乳头和味蕾的变化。结果 照射后大鼠舌菌状乳头和味蕾第 5天明显萎缩、退化、消失 ,第 10～ 2 0天达到最高峰 ,第 30天有少量菌状乳头和味蕾开始再生 ,第 6 0天菌状乳头和味蕾明显再生 ,有部分菌状乳头仍呈萎缩状 ,未见到再生的味蕾。结论 治疗剂量的6 0 Co照射头颈部 ,舌菌状乳头和味蕾的损伤是极其严重的 ,这些损伤能够再生 ,但不完全。

Objective To observe the morphological changes and the regenerating ability of the fungiform papillae and taste buds after +{60}Co radiation with clinical doses in rats.Methods The heads, faces and necks of 30 SD rats were radiated with a large dose and one time of +{60}Co in the clinical radiation. The general living condition and the number and shape of the fungiform papillae and taste buds of the tongues were observed after the radiation in rats.Results In the group of +{60}Co radiation, the animals had wilting, decreasing appetite, losing weight. The heads, faces and necks of animals appeared redness, peeling of hair, increasing of secretions in 5 days after the +{60}Co radiation. The changes reached the summit in 10 days and the general living condition of the animals recovered in 60 days. The fungiform papillae and taste buds of the animals appeared degeneration, atrophy and collapsing in 5 days after the +{60}Co radiation. The injuries reached the summit in 10～20 days and the fungiform papillae and taste buds regenerated partially, and the some atrophied fungiform papillae and taste buds were not regenerated in 60 days.Conclusion The damage to fungiform papillae and taste buds of tongue following the +{60}Co radiation with the clinical doses was very serious. The damaged fungiform papillae and taste buds can regenerate partially, but not completely.