酚妥拉明治疗小儿急性肾小球肾炎高血压疗效探讨

Curative effect study of phentolamine in treatment of acute glomerulonephritis hypertension

目的 探讨酚妥拉明治疗小儿急性肾小球肾炎高血压的疗效。方法 对 5 0例急性肾小球肾炎高血压患儿随机分两组 ,均给以抗生素、利尿剂 ;治疗组以酚妥拉明加入 10 %葡萄糖液 10 0 ml静滴 ,用法是每次 0 .3～ 0 .5 mg/ kg,每日 1～ 2次 ,最大量不超过每次 10 m g。结果 治疗组未发生高血压脑病及任何药物毒副反应 ,血压恢复时间、肉眼血尿消失时间、水肿消失时间经统计学处理 ,P<0 .0 1,两组相比差异有显著性。结论 酚妥拉明治疗急性肾小球肾炎高血压的效果是明显的 。

Objective To study the curative effects of phentolamine in treatment of acute glomerulonephritis hypertension.Methods Fifty patients suffering acute glomerulonephristis hypertension were divided into two groups at random.They were all given antibiotics and diuretic.The control group was given 100 ml intravenous injection of 10% glucose and phentolamine,0.3～0.5 mg/kg per time,1～2 times per day.The maximum dosage was not over 10 mg per time.Results No hypertension brain disease and medical side effect occure in the control group.Blood preasure renewable time,naked eye hematuria and dropsy disappearing time were treated by statistics(P<0.01).There were notable differences between the two groups.Conclusion The effect of phentolamine is very obvious in the treatment of acuts glomerulonephritis hypertension.It can convert the patient's condition from danger into safty.