不稳定性心绞痛患者C—反应蛋白变化的临床意义

Changes of C-reactive Protein and Its Clinical Significance in Unstable Angina Pectoris

目的 :探讨不稳定性心绞痛 (UAP)患者血清C—反应蛋白 (CRP)变化的临床意义。方法 :选择6 0例UAP患者为观察组 ,2 0例稳定性心绞痛 (SAP)患者为对照组 ,分别取血测定CRP ,观察组患者行冠状动脉造影 (CAG)检查。分析CRP在两组中的升高情况以及与观察组患者的临床状况、冠状动脉 (CA)病变的关系 ,并对观察组患者随访 6个月 ,观察心脏事件发生率。结果 :①观察组患者中CRP值明显高于对照组(P <0 0 1)。②观察组患者中 ,CRP值随心绞痛分级的递增而呈递增趋势 ,CRP升高组CA复杂病变、心脏事件发生率高于CRP正常组 (P <0 0 1、P <0 0 5 ) ,但心绞痛病史短于CRP正常组 (P <0 0 5 )。结论 :①UAP患者CRP值明显高于SAP患者。

Objective:To investigate the changes of C-reactive protein(CRP) in patients with unstable angina pectoris(UAP),and to evaluate its clinical significance.Method:The level of CRP in blood was measured in 60 patients with UAP(observed group)and 20 patients with stable angina pectoris(SAP) as controls.Coronary angiography(CAG) was performed in observed group.The changes of CRP in two groups were compared.The relationship between the releasing CRP and clinical conditions,characteristics of coronary artery(CA) in observed group was analysed.Patients in observed group were followed up for 6 months,and the incidence of cardiac events was observed.Results:①The serum level of CRP in observed group was significantly higher than controls(P<0.01);②In observed group,the level of CRP increased with clinical Braunwald grade.In group with increasing CRP,the prevalence of complex CA lesions and cardiac events was higher,but the history of angima was shorter than that in group with normal CRP (P<0.05,P<0.05).Conclusion:①The level of CRP patients in UAP are higher than that of SAP ones.②CAP may be a predictor for conditions,severity of CA lesions and prognosis in UAP.