贝尼地平在原发性高血压患者中的应用

The Observation of Benidipine for Essential Hypertension Patients

目的:观察盐酸贝尼地平治疗原发性轻中度高血压患者的疗效、安全性。方法:采取随机双盲对照观察法。原发性轻中度高血压的患者经安慰剂治疗两周,血压符合入选标准者,随机分为二组。分别给予盐酸贝尼地平4mg每日1次或氨氯地平5mg每日1次,第2周末,如舒张压≥90mmHg则剂量加倍,继续治疗6周。观察贝尼地平降压疗效及安全性。结果:两组血压治疗后均显著下降,治疗前后均有显著差异(P<0.001),但二组之间无显著差异(P>0.05)不良反应在两组间无统计学差异。心率的改变两组治疗前后无统计学差异(P>0.05)。结论:贝尼地平能有效降低轻中度原发性高血压患者的血压,疗效与氨氯地平组无统计学差异。具有较好安全性和耐受性。

Objective:To study hypotensive efficacy and security of benidipine during the treatment in the patients who suffered from mild-moderate essential hypertension.Methods: A randomized and double blind way performed. Patients with essential hypertension (blood pressure was considered eligible after treatment with placebo for 2 weeks)were randomly divided into two groups .They were administered benidipine 4mg once daily or amlodipine once daily for two weeks,respectively.If DBP≥90mmHg at the end of the second week,the dosage of drug was doubled,and continued to administer benidipine or amlodipine for another six weeks. Hypotensive efficacy and security were observed during the whole study period. Results: Blood pressure decreased significantly in both groups (P<0.001). The differences of decreasing range in each group on both diastolic and systolic were no statistically significant(P>0.05). The side effects between two groups were no statistically significant as well as the heart rate changes before and after the treatment(P>0.05). Conclusion: Benidipine may efficiently reduce the blood pressure of the mild-moderate essential hypertension patients and compare with amlodipine, the differences of its treatment functions are no statistically significant, which has fairly good security and tolerability characters.