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非甾体类抗炎药和心血管事件的相关性 被引量:2

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摘要 非甾体类抗炎药(Non-steroidal anti-inflammatorydrugs,NSAIDS)作为解热、镇痛、抗炎的重要药物广泛应用于临床,但同时这一类药在心血管方面安全性的评价也越来越引起重视,本文通过对一系列的临床研究进行分析,发现NSAIDS特别是特异性环氧合酶(COX)-2抑制剂能显著增加心血管事件[血栓事件、充血性心力衰竭、高血压、心肌梗死(MI)、严重的冠心病]的发病率.
作者 杨琼 秦明照
出处 《中国医药导刊》 2005年第1期50-52,共3页 Chinese Journal of Medicinal Guide
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  • 1Ray WA,Stein M,Daugherty JR, et al.COX-2 seletive non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease.Lancet,2002;360:1071~1073.
  • 2Solomon DH,Schneeweiss S, Levin R, et al. Relationship between selective COX-2 inhibitors and acute myocardial infarction in older adults.Circulation,2004;109(17):e9039~9040.
  • 3Widlandky,Price DT,Gokce N,et al. Short-and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension.Hypertension, 2003;42(3):310~315.
  • 4Verma S,Raj SR,Shewchuk L, et al. Cylooxygenase-2 blockade does not impair endothelial vasodilater function in healthy volunteers:randomized evaluation of rofecoxib versus naproxen on endothelium dependent vasodilation. Circulation,2001,104:2879~2882.
  • 5Ruschitzka F, Chenevard R, Hurlimann D, et al.Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation,2003; 107(3):405 ~409.
  • 6Bonbardier C, laine L, Reicin A,et al. Comparison of upper gastrointestinal toxicity of refecoxib and naproxeu in patients with rheumatoid arthritis VIGOR Study Group. N Engl J Med,2000;343:1520~1528.
  • 7Silverstein FE, Faith G, Goldsteim JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis:the CLASS Study:A randomized controlled trial Celecoxib Long-term Arthritis Safty Study.JAMA, 2000 284:1247~1255.
  • 8Mamdani M,Juurlink DN,Douglas L,et al. Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcome in elderly patients:a population-based cohort study. Lancet,2004;363:1051~1056.
  • 9Bleumink GS, Feenstra J,Sturkenboom MC,et al. Non-steroidal anti-inflammatory drugs and heart failure. Drugs,2003;63(6):524~534.
  • 10Krum H,Liew D, Aw J, et al. Cardiovascular effects of selective cyclooxygenase-2 inhibitors. Expert Rev Cardiovasc Ther,2004;2(2):265~270.

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