慢性乙型肝炎病毒感染者合并甲型肝炎病毒感染的临床特点与转归

ANALYSIS OF CLINICAL CHARACTERISTICS AND RECOVERY OF CHRONIC HEPATITIS B PATIENTS WITH SUPERINFECTION OF HEPATITIS A VIRUS

目的 观察慢性乙型肝炎重叠甲型肝炎病毒感染的临床特点及其病情转归。方法 以血清HBsAg和抗HAV -IgM均阳性患者 37例作为重叠组 ,测定血清谷丙转氨酶、总胆红素及统计恢复正常天数并与单纯慢性乙型肝炎进行对照分析。结果 重叠组慢性肝炎重度、慢性重型肝炎例数明显高于单纯慢性乙型肝炎 (P <0 0 5 ) ;血清谷丙转氨酶和总胆红素水平及恢复正常天数、病程均高于单纯慢性乙型肝炎 (P <0 0 1)。结论 慢性乙型肝炎重叠甲型肝炎病毒感染后病情趋向重症化 ,病程延长。

Objective To observe clinical characteristics and recovery of the chronic hepatitis B with superinfection of hepatitis A virus. Metho ds 37 cas es that HBsAg and antibody to hepatitis A virus were simultaneously positive wer e de-fined as the superinfection group. 30 cases with only HBV infection were d ef ined as the control group. Cases of two groups were detected ALT and TSB. The re covery normal days of ALT and TSB in patients were counted. Results The numbers of chronic hepatitis B severe type and fulminant hepatitis in the superinfection group were significantly more than that in the control group (P<0.05). ALT and TSB were significantly higher (P<0.01). The co urse of the disease were significantly longer (P<0.01). Conclus ion The disease tends to severity, while the chronic hepatitis B is sup erinfceted with hepatitis A virus and the course of the disease is relatively lo nger.