冬虫夏草对肾性高血压大鼠血管重构的影响

Effect of Codyceps Sinensis on Hypertensive Vascular Remodeling

目的 :观察冬虫夏草对肾性高血压大鼠心肌肥厚、血管重构的影响。方法 :体重为 160～ 180 g健康雄性 Wistar大鼠随机分为对照组、高血压组及治疗组 ,于术后第 10天大鼠灌胃 (ig)冬虫夏草煎剂 2 ml,每日两次 (bid) ,连续 2 0天 ,观察冬虫夏草对心肌肥厚、血管重构的影响。结果 :冬虫夏草明显改善高血压大鼠血压、心肌肥厚及血管重构。结论 :冬虫夏草对肾性高血压有治疗作用。

Objective: To observe the effect of Codyceps sinensis on hypertensive cardiac hypertrophy and vascular remodeling. Methods: Wistar rats were treated ig with Codyceps sinensis twice a day for 4 weeks. The effect of Codyceps sinensis on hypertensive cardiac hypertrophy and vascular remodling were investigated. Results: The increase of blood pressure in RH rats could be prevented significantly by treatment with Codyceps sinensis and it's cardiac hypertrophy and vascular remodeling was reversed. Conclusion: Codyceps sinensis has a curable role on renal hypertensive rats.