摘要
采用反相高效液相色谱法测定了新肿瘤光化学诊治剂(PsD-007)的化学组成,通过与确认品的对照测定,进一步阐明了 PsD-007是由 HP、MHD、AHD、HVD、DMD、MVD 和 Pp 等7种不同卟啉所组成,从而使 PsD-007成为第一种具有确定的化学组成、各成分化学结构和肿瘤光生物活性成分的肿廇光化学诊治剂。
The chemical composition of the new tumor-photochemodiagnostic and photochem-
otherapeutic agent(PsD-007)was determined by the reversed-phase HPLC.It has been further
confirmed by HPLC analysis compared the components of PsD-007 with their corresponding
authentic samples obtained by synthetic method,that PsD-007 is composed of 7 different
porphyrins:Hp、MHD、AHD、HVD、DMD、MVD and Pp.Thus,PsD-007 becomes the first
kind of photochemodiagnostic and photochemotherapeutic agent with definite composition and
known structures of all of its components as well as explicit tumor-photobiologically active
components.
关键词
高效液相色谱
PSD-007
抗癌药
成分
Reversed-phase HPLC
Tumor-photochemodiagnostic and photochemotherapeutic agent(PsD-007)
Chemical composition
