血清LSA、AFP联合检测对原发肝癌的诊断价值

The Values of Co-determinating Serum LSA and AFP in Primary Hepatocarcinoma Diagnosis

测定74例原发肝癌及94例肝脏良性疾病患者血清ISA与AFP的结果表明:ISA对原发肝癌的敏感度和特异性为82.4%和94.7%,AFP则为70.3%;两法诊断准确度分别为89.3%和77.4%,LSA显著高于AFP(P<0.01)。将两法联合应用,以两项及其中任何一项阳性者为阳性,对原发肝癌的敏感度为97.3%,可作为肝癌初筛指标,但假阳性亦增加;以LSA与AFP均阳性者为阳性,虽敏感度下降(52.7%),但尚未见到假阳性,故可作为原发肝癌鉴别指标。对仅LSA或AFP一项阳性者,则作为可疑肝癌,应进一步监测,结合临床表现及其它检查综合判断。

The results of determinating serum lipid—bond sialic acid (LSA) and AFP of 74 cases of primary hepatocarcinoma (PHC) and 94 cases of benign hepatic diseases showed: (1)The sensitivity and specificity of LSA to PHC were 82.4% and 94.7%, and those of AFP were 70.3% and 83.3%; the accuracies of LSA and AFP were 89.3% and 77.4% respectively, the former was more accurate (P<0.01). (2)When combined assaying the both and took LSA or AFP or both positive cases as positive, the sensitivity was enhanced to 97.3% and could be used as a screenning index of PHC;took those both LSA and AFP pos(?)ve as positive, the sensitivity was decreased to 52.7% but there was no false positive, so could be used to definitely diagnose PHC.