摘要
脂肪脂合酶(FAS)在恶性肿瘤中表达增高,酶活性增强。FAS的过度表达与肿瘤的发生、演变、侵袭、预后有关。了解肿瘤细胞中FAS的作用为肿瘤的诊断、治疗提供新的思路。浅蓝菌素、C75是FAS的抑制剂,是肿瘤药物治疗的的靶位。
Many primary carcinomas express high levels of FAS and enzyme activity.The overexpression of FAS is associated with production, change,invasion and prognosis of the tumor. Further research on its tumor biolog y and metabolism pathway can led to new approach in cancer diagnosis and therapy .Cerulenin and C75 which are FAS inhibitors,are target pathways for chemotherapy development.
出处
《中国癌症杂志》
CAS
CSCD
2005年第1期77-80,共4页
China Oncology
关键词
脂肪脂合酶
肿瘤
浅蓝菌素
C75
凋亡
预后
fatty acid synthase
neoplasms
cerulenin
C7 5
apoptosis
prognosis
