硫酸二乙酯法合成N-乙基间甲苯胺——芳胺N-烷基化研究(Ⅳ)

SYNTHESIS OF N-ETHYL-m-TOLUIDINE BY DIETHYL SULFATE——The Serial Studies on N-Alkylation of Aromatic Amines (Ⅳ)

N-乙间甲苯胺是制备彩色胶卷的显影套药CD-2,CD-3,CD-4和高档酸性染料,分散染料的重要中间体。它的制备与合成主要有:气相法、中压液相法、溴乙烷法和磷酸二乙酯法。这些合成方法各有优点与不足。用硫酸二乙酯合成N-基间甲苯胺尚未见有文献报道。硫酸二乙酯是一种较常用的乙基化试剂,可是它的反应活性比较高,容易生成N,N-二乙基芳胺。

The authors have synthesized N-ethyl-m-toluidine by diethylsulfate as alkylation reagent.The reaction condition is rather mild, theprocedure is vrery convenient and the yield is high.The percert conver-sion of m-toluidine reaeched 88.4% and the selectivity of product was86.1%.The authors have also studied the effects of temperature,solvent,time and dose of diethyl sulfate on the reaction.The optimum reactionconditions have been found and a new route have bevn offered to thesynthesis of N-ethyl-m-toluidine