原发性高血压患者血清利钠肽水平的变化

Changes of Serum Levels of Natriuretic Peptides in Patients with Essential Hypertension

目的:研究原发性高血压(EH)患者血清利钠肽(ANP,BNP,CNP)水平的变化,及其与高血压分期和靶 器官损害间的关系。方法:放射免疫分析测定112例EH患者和47例非高血压患者的血清利钠肽(ANP,BNP, CNP)水平,并进行对照统计分析。结果:EH组血清ANP,BNP,CNP水平均较对照组显著增高(P均<0.01),而 且与平均动脉压成显著正相关(P均<0.01),但与体重指数无相关性意义,男女组间无统计学差异。Ⅰ、Ⅱ、Ⅲ期组 间平均血清ANP,BNP,CNP水平依次显著性递增(P均<0.05),不同分期的EH患者之间血清ANP,BNP,CNP水 平均有明显差异(P均<0.05)。EH患者中伴心脑肾并发症组血清ANP,BNP,CNP水平显著高于无并发症组(P 均<0.01)。结论:EH患者血清ANP,BNP,CNP水平显著增高,且与平均动脉压、高血压分期及是否伴有并发症 相关,提示ANP,BNP,CNP变化与病情严重程度及高血压的靶器官损害相关并有助于预后判断。

Objective To explore the changes of the serum natriuretic peptides levels in patients with essential hypertension (EH) and to evaluate the relationship between the serum natriuretic peptides levels and stage of hypertension as well as target organ injury. Methods The serum levels of atrial and brain and C type natriuretic peptides (ANP, BNP, CNP) were determined with radioimmunoassay in 112 EH patients and 47 controls. Results The serum levels of natriuretic peptides (ANP, BNP, CNP) in EH patients were significantly higher than those in the controls (P<0.01), and were positively correlated to the mean arterial pressure (P<0.01) but not to body mass index and sex. The serum levels of natriuretic peptides (ANP, BNP, CNP) increased gradually from stage Ⅰ to stage Ⅲ EH patients and the differences among those in successive stages were significant (P<0.05), The serum levels of natriuretic peptides (ANP, BNP, CNP) in patients with renal and/or cardio and/or cerebral vascular complications were significantly higher than those in patients without complications (P<0.01). Conclusion The changes (increase) of serum levels of natriuretic peptides (ANP, BNP, CNP) in EH patients were closely related to the severity of the disease process and target organ injuries and might serve as an useful outcome predictor.