淋病患者治疗前后血清TNF和SA检测的临床意义

Clinical Significance of Determination of Changes of Serum TNF and SALevels After Treatment in Patients with Gonorrhea

目的:探讨淋病患者治疗前后肿瘤坏死因子(TNF)和唾液酸(SA)含量的变化。方法:分别应用放 射免疫分析和分光光度计法对42例淋病患者进行治疗前后血清TNF、SA含量检测,并与35名正常健康人作 比较。结果:治疗前患者血清中TNF、SA含量非常显著地高于正常人组(P<0.01),经治疗后2周则与正常人 比较无显著性差异(P>0.05)。结论:检测淋病患者血清中TNF、SA含量与疾病的发生密切相关。

Objective To investigate the changes of serum TNF and sialic acid (SA) levels after treatment in patients with gonorrhea. Methods Serum TNF (with RIA) and SA (with spectrophotometer ) levels were measured both before and after treatment in 42 patients with gonorrhea as well as in 35 controls. Results Before treatment, the serum levels of TNF and SA were significantly higher than those in the controls (P<0.01). After treatment, the levels markedly dropped and approached those in controls (P>0.05). Conclusion Changes of serum levels of TNF and SA could reflect the severity of infection in patients with gonorrhea.