腺苷脱氨酶、癌胚抗原的检测对结核性和恶性胸腔积液的诊断价值

Diagnostic Value of ADA and CEA Between Tuberculous and Malignant Thoracico Abdominal Cavity Exudates

目的 :探讨腺苷脱氨酶 (ADA)和癌胚抗原 (CEA)的检测对结核性与恶性胸腔积液的鉴别价值。方法 :分别采用酶联免疫吸附试验 (EL ISA)对 12 0例胸腔积液患者的 ADA、CEA进行检测分析。结果 :结核性胸腔积液和恶性胸腔积液患者 ADA活性分别为 (46 .2± 18.6 ) U/ L和 (8.3± 5 .5 ) U/ L ,二者间差异存在显著性 (P<0 .0 1)。同时 ,抗结核治疗后 ,结核性和恶性胸腔积液 ADA活性分别为 (2 2 .8± 8.3) U/ L 和 (7.7± 4 .2 ) U/ L。结核性胸腔积液和恶性胸腔积液患者 CEA阳性检出率分别为 2 .6 %和 71.4 % ,特异性为 97.4 % (P<0 .0 1)。结论 :胸腔积液 ADA和CEA的检测对结核性与恶性胸腔积液有鉴别诊断价值。ADA还可以作为抗结核治疗疗效观察的指标。

Objective To study the differential value of adenosine deaminase adenase(ADA) and carcinoembryonic antigen(CEA) between tuberculous and malignant thoracico abdominal cavity exudate.Methods ADA and CEA of 120 cases of thoracico abdominal cavity exudates were analyzed by enzyme linked immunosorbent assay(ELISA) and ammoniacal reagent method.Results The ADA activity of tuberculous and malignant exudates was (46.2±18.6)U/L and (8.3±5.5)U/L respectively, the ADA activity was different obviously(P<0.01). Their ADA avtivity was (22.8±8.3)U/L and (7.7±4.2)U/L after receiving anti-tuberculous treatment. The positive rates of CEA of tuberculous and malignant exudates were 2.6 % and 71.4 % respectively;the specificity was 97.4 %(P<0.01).Conclusion Examination of thoracico abduninal cavity exudates ADA and CEA have the differevtial diagnosis value between tuberculous and malignant thoraci cobdorninal cavity exudates.