恶性肿瘤患者血清中肝细胞生长因子定量测定的临床价值

The Clinical Value of Measurement of Serum HGF Content in Patients of Malignant Tumor

目的 :探讨血清中肝细胞生长因子 (hepatocyte growth factor/ scatter factor,HGF/ SF)测定在恶性肿瘤患者诊断中价值。方法 :采用酶联免疫测定 (EIA)法定量测定 5 8例恶性肿瘤患者 (已确诊 )血清中 HGF含量 ,同时对2 0例恶性肿瘤患者术后复查阴性患者 (指术后复查未再发现肿瘤 ) ,12例癌前病变患者 ;18例健康对照者进行检测。结果 :1恶性肿瘤患者组同健康对照组相比血清中 HGF含量显著升高 (P<0 .0 1) ;而其他各组与健康对照组相比较差异无显著性意义 (P>0 .0 5 )。结论 :恶性肿瘤患者血清中 HGF含量明显升高并同肿瘤的侵袭状态密切相关 ,HGF可能成为一项有价值的用于恶性肿瘤患者筛选诊断和术后随诊的肿瘤标记物。

Objective To explore the clinical value of measurement of the serum content of HGF in malignant tumor patients.Methods Serum samples of malignant tumor patients(n=58) were examined for HGF content measurement by the quantitative EIA.Also serum HGF contents were measured in the control groups,which included 20 cases under going surgical procedure previously for malignant tumor but now being without tumor recurrence,12 cases of premalignant tumorous lesions and 18 healthy volunteers.Results The level of total HGF in malignant tumor group was significantly higher than those in other groups and the contents of HGF increased with tumor grade and stage increment.No significant differences of serum HGF contents was seen between the primary tumors and recurrent tumors.Conclusions The contents of total HGF in serum of malignant tumor patients was significantly increaed and closely related to the invasive behavior of the tumors.HGF may be a new useful tumor marker for screening and monitoring malignant tumor patients.