萘哌地尔衍生物BWYJ对家兔血小板聚集的影响

Effect of naftopidil ' ramification -BWYJ on platelets aggregation of rabbit

目的 观察萘哌地尔衍生物 (BWYJ)对家兔体外血小板聚集率的影响。方法 采用体外血小板比浊法 ,利用不同的诱导剂 ,观察BWYJ对血小板聚集率的抑制作用。结果 BWYJ对肾上腺素所引起的血小板聚集有明显的抑制作用 ,高浓度BWYJ对ADP所引起的血小板聚集也有抑制效应。结论 BWYJ具有抑制血小板聚集的作用。

Objective To observe the effect of naftopidil ' ramification -BWYJ, on the platelet aggregation of rabbit. Methods Using turbidimetry to determine the inhibiting rafe of BWYJ to platelets aggragation induced by adanosine diphosphate(ADP) and adrenaline. Results BWYJ10 5 and 10 4mol.L 1significantly can inhibit the platelet aggregation induced by Adernaline, it can also inhibit the platelet aggregation induced by ADP but when its concentration reaching to 10 -4 mol·L -1 . Conclusions BWYJ has inhibiting effect on the platelet aggregation.