儿童分化不良性星形细胞瘤17例临床病理观察及预后分析

An observation for clinical pathological characteristics and prognosis analysis of poorly-differentiated astrocytoma in seventeen children

目的 探讨儿童分化不良性星形细胞瘤的临床病理特征及预后。方法 对 17例儿童分化不良性星形细胞瘤作回顾性临床病理观察及免疫组化标记。结果 发病年龄从 4 .5～ 15a ,平均 11.2a ,有颅内高压症状者 14例 ,占 82 .3% ,共济失调者 11例 ,占 6 4 .7% ,二者共有者 8例 ,占 4 7%。结论 儿童分化不良性星形细胞瘤是一种好发于小脑 ,临床以颅内高压为主要症状 ,愈后较差且易术后复发的肿瘤。

Objective To study clinical pathological characteristics and prognosis of poorly differentiated astrocytoma. Method Retrospective analysis and immunohistochemical staining were carried out in seventeen children with poorly differentiated astrocytoma. Results The age ranged from 4.5 to 15 years, average age was 11.2 years, in which 14 cases had intracranial hypertension syndrome, accounted for 82.3%, 11 cases with ataxia accounted for 64.7%, 8 cases with both symptoms accounted for 47% of all cases. Conclusions poorly differentiated astrocytoma often occurs in cerebellum of children with intracranial hypertension as main clinical symptom, its prognosis is poor, the kind of tumor has the tendency to relapse after resection.