碱性成纤维细胞生长因子对脑创伤后机体免疫功能的影响

EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR ON SYSTEMIC IMMUNE FUNCTION AFTER HEAD TRAUMA

目的 :研究碱性成纤维细胞生长因子 (b FGF)对大鼠脑创伤后机体免疫功能的影响。方法 :实验动物为 2 5 0～ 30 0 g的雄性 Wistar大鼠 ,随机分为实验组和对照组 ,每组 8只 ,用α-醋酸萘酸脂酶 (ANAE)组化染色方法 ,检测脑创伤大鼠使用 b FGF后外周血 ANAE阳性细胞。观察脑创伤后 ,b FGF对机体免疫功能的保护作用。结果 :b FGF能显著提高外周血中 ANAE阳性细胞的百分比。结论 :b

Objective:To explore effects of basic Fibroblast Growth Factor(bFGF) on rats' systemic immune functions after head trauma.Methods:Wistar rats were randomly divided into test and control groups. ANAE histochemical methods were adopted to observe protective effects of bFGF on rats' systemic immune functions after head trauma.Result:bFGF could increase percentage of ANAE positive cells of peripheral bloods.Conclusion:bFGF could strengthen systemic cellular immune functions.