高危尿毒症患者肾移植术后早期监测全血环孢素A浓度的临床意义

Clinical Evaluation of Monitoring cas Whole Blood Concentration of High Risk Uremia in the Early Post Transplantation

应用荧光偏振免疫法(FPIA)对30例高危尿毒症患者肾移植术后早期的全血环孢素A(CsA)浓度进行动态监测。结果表明:高危尿毒症患者肾移植术后早期的全血CsA浓度明显高于对照组,术后早期急性排斥反应的发生率低,但是容易发生CsA的肝脏及胰腺的毒副作用。本资料分别探讨了不同高危受者术后应用CsA免疫抑制治疗的特点。

The CsA whole blood concentration in 30 cases of high risk uremia was monitored by the tluo-rescence polarization immunoassay (PLA). The conclusion was (1)the CsA blood concentration of high risk uremia was much higher than the control at the early stage of post transplantation. (2)In cidence of acute rejection of high risk uremia was lower than the control.(3)The incidence of drug side effect to liver and pancreas was higher than the control. The characters of CsA immunosuppressive treatment at the early stage of post transplantation were discussed among different high risk uremia.