炎症在高血压病并发陈旧性心肌梗死中的作用

Inflammation in Essential Hypertension Complicated with Old Myocardial Infarction

目的 探讨炎症在高血压病并发陈旧性心肌梗死中的作用。方法 高血压病并发陈旧性心肌梗死患者 2 7例、高血压患者 2 8例和 30例健康人 ,分别用放免法测定血浆炎症介质肿瘤坏死因子α(TNF α)、白介素 1β(IL 1β)、白介素 6 (IL 6 )含量 ,用免疫比浊法测定血浆炎症介质C反应蛋白 (CRP)含量。同时常规测定体重指数、吸烟指数、血压、血浆空腹血糖、血脂、尿酸。结果 高血压患者血浆CRP、TNF α、IL 1β、IL6含量水平升高 ,并发陈旧性心肌梗死患者进一步升高。多元线性回归分析 ,血浆CRP、TNF α、IL 1β、IL6含量与体重指数、收缩压 (SBP)、血浆空腹血糖 (FPG)、甘油三酯(TG)呈直线正相关 ,且SBP、FPG、TG进入上述血浆炎症介质含量直线回归方程。结论 高血压病并发或不并发陈旧性心肌梗死患者均有炎症活动 ;SBP、FPG。

Objective To study the significance of inflammation on essential hypertension (EH) complicated with old myocardial infarction(OMI). Methods The plasma C-reactive protein(CRP) level was measured with immunonephelometry, plasma tumor necrosis factor-α(TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels by radioimmunoassay in 28 patients with EH, 27 patients with EH complicated with OMI, and 30 healthy people as normotensive controls. Results The levels of plasma CRP, TNF-α, IL-6, and IL-1β were higher in patients with EH compared to normotensive controls( P <0.01 ) and even more higher in patients with EH accompanied with OMI. Multiple linear regression analysis showed increase in CRP, TNF-α, and IL-6 levels was related with SBP, FPG, and TG. Conclusion Inflammation plays a pivotal role in EH with or without OMI. SBP, FPG and TG may involve in myocardial infarction by inflammation.