喉癌的MRI形态学表现与其增殖细胞核抗原表达的相关性

Correlations of MRI morphologic features and the expression of proliferating cell nuclear antigen in laryngeal cancer

目的 探讨喉癌的MRI形态学特征与其增殖细胞核抗原表达的相关性。方法 对 41例喉癌患者术前行磁共振SE序列平扫 ,其中 2 0例加行增强扫描。术后标本用ABC免疫组化技术进行PCNA半定量测量。结果 ①前组声门上型喉癌更易侵犯会厌软骨和室带 (P <0 .0 5 ) ;后组更易侵犯杓状软骨和后联合 (P <0 .0 5 )。声带和杓会厌皱襞受累提示癌组织PCNA标记指数 >75 %的可能性大 (P <0 .0 5 )。②声门型喉癌前联合受累组的PCNA标记指数高于未受累组 (P <0 .0 5 )。③甲状软骨侵犯阳性组及颈淋巴结转移阳性的PCNA标记指数均高于阴性组 (P <0 .0 5 )。结论 喉癌的某些MRI形态学表现可以在一定程度上推测PCNA标记指数 ,了解其增殖活性。

Objective To explore the correlations of MRI morphologic features and the expression of proliferating cell nuclear antigen (PCNA) in laryngeal cancer. Methods Unenhanced MR SE sequences were performed on 41 patients with laryngeal carcinoma, contro enhenced SE T1WI sequences were performed on 20 cases before operation. The expression of PCNA was semiquantitatively investigated through ABC immunohistochemical technique. Results ①Anterior group of supraglottic cancer is apt to attack epiglottic cartilage and false cord while posterior group to attack arytenoids cartilage and posterior commissure ( P <0.05). The invasion of true cord and arytenoid epiglottic fold cued opportunity of PCNA label index >75%. ②PCNA label index of glottic cancer with anterior commissure invasion was higher than that of the negative group ( P <0.05). ③PCNA label index of the group with thyroid cartilage invasion and the group with metastasis of cervical lymph node was higher than that of the negative group ( P <0.05). Conclusion Morphologic appearances of MRI can predict PCNA label index and the proliferating ability in a certain degree.